The police commissioner for the state of Kano, Aderenle Shinaba, said one suspect was detained after the blast on Monday and that his vehicle had been seized for investigation.
The commissoner said that Boko Haram Islamic extremists were suspected.
One student said people ran out of the school of hygiene yelling "get out! It's a bomb".
It was the third bomb blast in four months in Nigeria's second largest city.
Boko Haram did not immediately claim responsibility but the school matches two of its targets, of schools and western medicine.
The group has attracted international condemnation since April when it kidnapped more than 200 schoolgirls, from the town of Chibok, in Borno state, most of whom remain captive.
Nigeria's government has not succeeded in curbing the uprising
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